<p> Proteins in this entry are related to ClpA (<db_xref db="SWISSPROT" dbkey="P0ABH9"/>) from <taxon tax_id="562">Escherichia coli</taxon>. ClpA is an ATP-dependent chaperone and part of the ClpAP protease that participates in regulatory protein degradation and the dissolution and degradation of protein aggregates [<cite idref="PUB00020759"/>]. ClpA recognises sequences in specific proteins, which it then unfolds in an ATP-dependent manner and transports into the degradation chamber of the associated ClpP protein [<cite idref="PUB00020750"/>, <cite idref="PUB00020760"/>]. A small adaptor-like protein, ClpS, modulates the activity of ClpA and is an important regulatory factor for this protein [<cite idref="PUB00020738"/>]. It protects ClpA from autodegradation and appears to redirect its activity away from soluble proteins and toward aggregated proteins.</p> ATP-dependent Clp protease ATP-binding subunit ClpA